Evaluation of Senegalese plants used in malaria treatment: Focus on Chrozophora senegalensis.
Identifieur interne : 001925 ( Main/Exploration ); précédent : 001924; suivant : 001926Evaluation of Senegalese plants used in malaria treatment: Focus on Chrozophora senegalensis.
Auteurs : F. Benoit-Vical ; P Njomnang Soh ; M. Saléry ; L. Harguem ; C. Poupat [France] ; R. NongoniermaSource :
- Journal of Ethnopharmacology [ 0378-8741 ] ; 2008-02-28.
Abstract
An ethnobotanical study was conducted in the Dakar area of Senegal to investigate the species used in the treatment of malaria. Seven plants are principally used: Cissampelos mucronata, Maytenus senegalensis, Terminalia macroptera, Bidens engleri, Ceratotheca sesamoides, Chrozophora senegalensis and Mitracarpus scaber. From a bibliographic study, it had been shown that the Cissampelos mucronata, Maytenus senegalensis and Terminalia macroptera have already been studied by several authors, and so only Bidens engleri, Ceratotheca sesamoides, Chrozophora senegalensis and Mitracarpus scaber were evaluated in the present study. For each plant, extracts were prepared with different solvents and tested in vitro on two chloroquine-resistant Plasmodium falciparum strains. Crude extracts from the leaves and the stems of Chrozophora senegalensis showed the best in vitro results. The IC(50) value of an aqueous extract of Chrozophora senegalensis was 1.6mug/ml without cytotoxicity. The in vivo antiplasmodial activity of Chrozophora extracts was determined by both the oral and the intraperitoneal ways. The stages of Plasmodium cycle targeted by Chrozophora were then studied in vitro. These results could justify the traditional use of this plant in malaria treatment.
Url:
DOI: 10.1016/j.jep.2007.10.033
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Hal, to step Corpus: 000087
- to stream Hal, to step Curation: 000087
- to stream Hal, to step Checkpoint: 000214
- to stream Main, to step Merge: 001931
- to stream Main, to step Curation: 001925
Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Evaluation of Senegalese plants used in malaria treatment: Focus on Chrozophora senegalensis.</title><author><name sortKey="Benoit Vical, F" sort="Benoit Vical, F" uniqKey="Benoit Vical F" first="F." last="Benoit-Vical">F. Benoit-Vical</name></author><author><name sortKey="Soh, P Njomnang" sort="Soh, P Njomnang" uniqKey="Soh P" first="P Njomnang" last="Soh">P Njomnang Soh</name></author><author><name sortKey="Salery, M" sort="Salery, M" uniqKey="Salery M" first="M." last="Saléry">M. Saléry</name></author><author><name sortKey="Harguem, L" sort="Harguem, L" uniqKey="Harguem L" first="L." last="Harguem">L. Harguem</name></author><author><name sortKey="Poupat, C" sort="Poupat, C" uniqKey="Poupat C" first="C." last="Poupat">C. Poupat</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID"> <orgName>Institut de Chimie des Substances Naturelles</orgName> <orgName type="acronym">ICSN</orgName> <desc> <address> <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UPR2301" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Nongonierma, R" sort="Nongonierma, R" uniqKey="Nongonierma R" first="R." last="Nongonierma">R. Nongonierma</name></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-00257547</idno><idno type="halId">hal-00257547</idno><idno type="halUri">https://hal.archives-ouvertes.fr/hal-00257547</idno><idno type="url">https://hal.archives-ouvertes.fr/hal-00257547</idno><idno type="doi">10.1016/j.jep.2007.10.033</idno><date when="2008-02-28">2008-02-28</date><idno type="wicri:Area/Hal/Corpus">000087</idno><idno type="wicri:Area/Hal/Curation">000087</idno><idno type="wicri:Area/Hal/Checkpoint">000214</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000214</idno><idno type="wicri:doubleKey">0378-8741:2008:Benoit Vical F:evaluation:of:senegalese</idno><idno type="wicri:Area/Main/Merge">001931</idno><idno type="wicri:Area/Main/Curation">001925</idno><idno type="wicri:Area/Main/Exploration">001925</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Evaluation of Senegalese plants used in malaria treatment: Focus on Chrozophora senegalensis.</title><author><name sortKey="Benoit Vical, F" sort="Benoit Vical, F" uniqKey="Benoit Vical F" first="F." last="Benoit-Vical">F. Benoit-Vical</name></author><author><name sortKey="Soh, P Njomnang" sort="Soh, P Njomnang" uniqKey="Soh P" first="P Njomnang" last="Soh">P Njomnang Soh</name></author><author><name sortKey="Salery, M" sort="Salery, M" uniqKey="Salery M" first="M." last="Saléry">M. Saléry</name></author><author><name sortKey="Harguem, L" sort="Harguem, L" uniqKey="Harguem L" first="L." last="Harguem">L. Harguem</name></author><author><name sortKey="Poupat, C" sort="Poupat, C" uniqKey="Poupat C" first="C." last="Poupat">C. Poupat</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-440" status="VALID"> <orgName>Institut de Chimie des Substances Naturelles</orgName> <orgName type="acronym">ICSN</orgName> <desc> <address> <addrLine>Avenue de la terrasse 91198 Gif sur yvette cedex</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation name="UPR2301" active="#struct-441569" type="direct"></relation> </listRelation> <tutelles><tutelle name="UPR2301" active="#struct-441569" type="direct"><org type="institution" xml:id="struct-441569" status="VALID"> <idno type="IdRef">02636817X</idno> <idno type="ISNI">0000000122597504</idno> <orgName>Centre National de la Recherche Scientifique</orgName> <orgName type="acronym">CNRS</orgName> <date type="start">1939-10-19</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.cnrs.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Nongonierma, R" sort="Nongonierma, R" uniqKey="Nongonierma R" first="R." last="Nongonierma">R. Nongonierma</name></author></analytic><idno type="DOI">10.1016/j.jep.2007.10.033</idno><series><title level="j">Journal of Ethnopharmacology</title><idno type="ISSN">0378-8741</idno><imprint><date type="datePub">2008-02-28</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>An ethnobotanical study was conducted in the Dakar area of Senegal to investigate the species used in the treatment of malaria. Seven plants are principally used: Cissampelos mucronata, Maytenus senegalensis, Terminalia macroptera, Bidens engleri, Ceratotheca sesamoides, Chrozophora senegalensis and Mitracarpus scaber. From a bibliographic study, it had been shown that the Cissampelos mucronata, Maytenus senegalensis and Terminalia macroptera have already been studied by several authors, and so only Bidens engleri, Ceratotheca sesamoides, Chrozophora senegalensis and Mitracarpus scaber were evaluated in the present study. For each plant, extracts were prepared with different solvents and tested in vitro on two chloroquine-resistant Plasmodium falciparum strains. Crude extracts from the leaves and the stems of Chrozophora senegalensis showed the best in vitro results. The IC(50) value of an aqueous extract of Chrozophora senegalensis was 1.6mug/ml without cytotoxicity. The in vivo antiplasmodial activity of Chrozophora extracts was determined by both the oral and the intraperitoneal ways. The stages of Plasmodium cycle targeted by Chrozophora were then studied in vitro. These results could justify the traditional use of this plant in malaria treatment.</p> </div></front></TEI><affiliations><list><country><li>France</li></country></list><tree><noCountry><name sortKey="Benoit Vical, F" sort="Benoit Vical, F" uniqKey="Benoit Vical F" first="F." last="Benoit-Vical">F. Benoit-Vical</name><name sortKey="Harguem, L" sort="Harguem, L" uniqKey="Harguem L" first="L." last="Harguem">L. Harguem</name><name sortKey="Nongonierma, R" sort="Nongonierma, R" uniqKey="Nongonierma R" first="R." last="Nongonierma">R. Nongonierma</name><name sortKey="Salery, M" sort="Salery, M" uniqKey="Salery M" first="M." last="Saléry">M. Saléry</name><name sortKey="Soh, P Njomnang" sort="Soh, P Njomnang" uniqKey="Soh P" first="P Njomnang" last="Soh">P Njomnang Soh</name></noCountry><country name="France"><noRegion><name sortKey="Poupat, C" sort="Poupat, C" uniqKey="Poupat C" first="C." last="Poupat">C. Poupat</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 001925 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 001925 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Main
|étape= Exploration
|type= RBID
|clé= Hal:hal-00257547
|texte= Evaluation of Senegalese plants used in malaria treatment: Focus on Chrozophora senegalensis.
}}
| This area was generated with Dilib version V0.6.33. |  |